MJENORYCIN A: ~INIIIUR STRUCTURAL REUUIRERENTS FOR BIOl_OCICAL ACTIVITY
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چکیده
A stepwise degradation of the oligosaccharide part of moenomycin A (2) was performed. The degradation products were assayed for antibiotic activity both in vivo and in an E.coli cell-free system. Units E, F, G, H, and I have been found -to be essential for full biological (in vitro) activity. _It is suggested that 2 is a competitive inhibitor of the peptidoglycan polymerase.
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تاریخ انتشار 2000